The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity
نویسندگان
چکیده
منابع مشابه
The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity.
GnRH and sex steroids play an important role in immune system modulation and development. GnRH and the GnRH receptor are produced locally by immune cells, suggesting an autocrine role for GnRH. Experimental studies show a stimulatory action of exogenous GnRH on the immune response. The immune actions of GnRH in vivo are, however, less well established. Oestrogen and androgen receptors are expre...
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The present thesis deals with different aspects of population pharmacokinetic/ pharmacodynamic (PK/PD) modelling of the male hypothalamic-pituitary-gonadal (HPG) axis. The thesis consists of a summary report and five scientific research papers. An overview of the main topics covered in the thesis is provided in the summary report including PK/PD modelling in drug development, the pathological, ...
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Recent evidence indicates that transthyretin (TTR), the major transport protein for thyroxine [1] and retinol binding protein [2], plays important roles in amyloidβ (Aβ) metabolism. Transthyretin has been demonstrated to bind Aβ in vitro [3,4] and in vivo [5,6], colocalize in Aβ plaques and within neurons containing intracellular Aβ [7], and recent evidence suggests it might act as a transport ...
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The hypothalamic-pituitary-gonadal (HPG) axis is active in the midgestational foetus but silenced towards term because of the negative feedback effects mediated by the placental hormones. This restraint is removed at birth, leading to reactivation of the axis and an increase in gonadotrophin levels. Gonadotrophin levels are high during the first 3 months of life but decrease towards the age of ...
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This article has demonstrated that stress and HPA axis activation affect the reproductive axis. Despite similarities in the HPA axis picture between women with major depression and those with hypothalamic amenorrhea and exercise or nutritional amenorrhea, no abnormalities in LH secretion have been documented in major depression. Lower estradiol in the follicular phase in depressed women and low...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2003
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1760293